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. 1987 Apr;69(4):1242-8.

Improved Results of Treatment of Adult Acute Lymphoblastic Leukemia

  • PMID: 3470055

Improved Results of Treatment of Adult Acute Lymphoblastic Leukemia

C A Linker et al. Blood. .

Abstract

We designed a treatment program to improve the outcome for adults with acute lymphoblastic leukemia (ALL). Treatment included a remission-induction phase followed by intensive alternating cycles of non-cross-resistant chemotherapy and prolonged oral maintenance therapy. Eighty-one consecutive previously untreated patients were entered on this study. Ninety-four percent of patients entered complete remission. A Kaplan-Meier analysis predicts that 53% +/- 9% (SEM) of patients in remission will remain free of disease at 3 years. Neither age, sex, WBC count, nor immunophenotype had a significant effect on remission duration. This program of intensive cyclical chemotherapy has improved the disease-free survival of patients with adult ALL.

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