Collagenase Tenotomy for Dupuytren Boutonniere

Plast Reconstr Surg. 2021 Nov 1;148(5):764e-768e. doi: 10.1097/PRS.0000000000008480.


Summary: Treatment of boutonniere Dupuytren disease is rare and is resistant to treatment because of altered tendon dynamics. The authors used a small dose of collagenase clostridium histolyticum for an enzymatic tenotomy of the distal interphalangeal joint and showed that hyperextension at the distal interphalangeal joint improved significantly. Fifteen patients with boutonniere Dupuytren disease with severe proximal interphalangeal joint contractures averaging -69 degrees of extension were included in the study. Ten patients had at least one previous intervention, including surgical fasciectomy, Digit Widget treatment, and needle aponeurotomy. Collagenase clostridium histolyticum enzymatic tenotomy was performed in-office as a wide-awake procedure. All patients received varying doses of collagenase clostridium histolyticum for volar Dupuytren disease enzymatic fasciotomy and 0.1 mg of collagenase clostridium histolyticum into the distal extensor tendon for tenotomy to treat boutonniere deformity at the same time. Collagenase clostridium histolyticum enzymatic tenotomy significantly improved total active motion of the finger by 41.0 degrees (p = 0.001). Loss of extension at both the metacarpophalangeal joint and the proximal interphalangeal joint also improved with gains of 11.7 (p = 0.04) and 20.7 degrees (p = 0.0005) of extension, respectively. The average distal interphalangeal joint hyperextension was improved from 29.7 degrees to 14.0 degrees (p = 0.002). The authors show that collagenase injection led to significant average improvement in joint contracture at all finger joints and significantly increased the arc of motion at the proximal interphalangeal joint and metacarpophalangeal joint. Although collagenase has been previously used for flexion contractures in Dupuytren disease, we believe it has a role in treating the distal interphalangeal joint hyperextension deformity associated with boutonniere deformity in Dupuytren disease as well.

Clinical question/level of evidence: Therapeutic, IV.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Dupuytren Contracture / physiopathology
  • Dupuytren Contracture / surgery*
  • Female
  • Finger Joint / physiopathology
  • Follow-Up Studies
  • Humans
  • Injections, Intralesional
  • Male
  • Microbial Collagenase / administration & dosage*
  • Middle Aged
  • Range of Motion, Articular
  • Retrospective Studies
  • Tendons / drug effects*
  • Tenotomy / methods*
  • Treatment Outcome


  • Microbial Collagenase