Assessment of total and regional bone mineral density using bioelectrical impedance vector analysis in elderly population

Sci Rep. 2021 Oct 27;11(1):21161. doi: 10.1038/s41598-021-00575-1.


This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2-L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2-L4, and BMDDFN, were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H (p < 0.001). The General Linear Model (GLM) regression results were as follows: BMDTotal = 1.473-0.002 R/H + 0.007 Xc/H, r = 0.684; BMDL2-L4 = 1.526-0.002 R/H + 0.012 Xc/H, r = 0.655; BMDDFN = 1.304-0.002 R/H + Xc/H, r = 0.680; p < 0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMDTotal, BMDL2-L4 and BMDDFN. R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon / methods
  • Aged
  • Aged, 80 and over
  • Aging / pathology
  • Algorithms
  • Bone Density*
  • Electric Impedance
  • Female
  • Femur Neck / diagnostic imaging
  • Femur Neck / growth & development
  • Humans
  • Male
  • Middle Aged
  • Osteoporosis / epidemiology*