microRNAs in female infertility: An overview

Cell Biochem Funct. 2021 Dec;39(8):955-969. doi: 10.1002/cbf.3671. Epub 2021 Oct 27.


Infertility impacts a considerable number of women worldwide, and it affects different aspects of family life and society. Although female infertility is known as a multifactorial disorder, there are strong genetic and epigenetic bases. Studies revealed that miRNAs play critical roles in initiation and development of female infertility related disorders. Early diagnosis and control of these diseases is an essential key for improving disease prognosis and reducing the possibility of infertility and other side effects. Investigating the possible use of miRNAs as biomarkers and therapeutic options is valuable, and it merits attention. Thus, in this article, we reviewed research associated with female diseases and highlighted microRNAs that are related to the polycystic ovary syndrome (up to 30 miRNAs), premature ovarian failure (10 miRNAs), endometriosis (up to 15 miRNAs), uterine fibroids (up to 15 miRNAs), endometrial polyp (3 miRNAs), and pelvic inflammatory (6 miRNAs), which are involved in one or more ovarian or uterine disease-causing processes.

Keywords: endometrial polyp; endometriosis; infertility; miRNA; pelvic inflammatory disease; polycystic ovary syndrome; premature ovarian failure; uterine leiomyoma.

Publication types

  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Infertility, Female / genetics*
  • MicroRNAs / genetics*


  • MicroRNAs