Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Chem Rev. 2021 Nov 24;121(22):13915-13935. doi: 10.1021/acs.chemrev.1c00712. Epub 2021 Oct 28.


Peptides have been extensively utilized to construct nanomaterials that display targeted structure through hierarchical assembly. The self-assembly of both rationally designed peptides derived from naturally occurring domains in proteins as well as intuitively or computationally designed peptides that form β-sheets and helical secondary structures have been widely successful in constructing nanoscale morphologies with well-defined 1-d, 2-d, and 3-d architectures. In this review, we discuss these successes of peptide self-assembly, especially in the context of designing hierarchical materials. In particular, we emphasize the differences in the level of peptide design as an indicator of complexity within the targeted self-assembled materials and highlight future avenues for scientific and technological advances in this field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Nanostructures* / chemistry
  • Peptides* / chemistry
  • Protein Conformation, beta-Strand


  • Peptides