In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges

Int J Stem Cells. 2022 May 30;15(2):113-121. doi: 10.15283/ijsc21122.


The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients' own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.

Keywords: Blastocyst complementation; Chimeras; Organ generation; Transplantation.

Publication types

  • Review