Concurrent exercise does not prevent recognition memory deficits induced by beta-amyloid in rats

Physiol Behav. 2022 Jan 1:243:113631. doi: 10.1016/j.physbeh.2021.113631. Epub 2021 Oct 29.

Abstract

Alzheimer's disease affects thousands of people worldwide. Alternatives aiming to prevent the disease or reduce its symptoms include different physical exercise configurations. Here we investigate the potential of concurrent exercise to prevent recognition memory deficits in an Alzheimer's disease-like model induced by the hippocampal beta-amyloid (Aβ) injection in Wistar rats. We demonstrate that the concurrent exercise, which included running and strength exercises performed in the same exercise session, is ineffective in preventing recognition memory deficits in the Aβ rats. Besides, higher levels of reactive oxygen species were found in the concurrent exercise group's hippocampus. The running exercise administrated alone prevented recognition memory impairments.

Keywords: Alzheimer's disease; Neurodegeneration; Running; Strength; Training.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alzheimer Disease* / complications
  • Alzheimer Disease* / prevention & control
  • Amyloid beta-Peptides* / metabolism
  • Amyloid beta-Peptides* / toxicity
  • Animals
  • Disease Models, Animal
  • Hippocampus / metabolism
  • Humans
  • Memory Disorders / etiology
  • Memory Disorders / prevention & control
  • Rats
  • Rats, Wistar

Substances

  • Amyloid beta-Peptides