PER-117: a new human ALL cell line with an immature thymic phenotype

Leuk Res. 1987;11(5):489-98. doi: 10.1016/0145-2126(87)90082-8.


A new cell line, PER-117, was established from bone marrow cells of an eighteen months old boy with an acute lymphoblastic leukaemia (ALL). The leukaemic origin of cell line PER-117 is indicated by its cytochemical, immunological and cytogenetic similarity to the patient's fresh leukaemic cells. PER-117 carries a marker chromosome which was identified as a translocation between chromosomes 1 and 11. The surface marker analysis revealed that the phenotype of PER-117 is RFB-1+, RFT-1+ (CD5), 3A1+ (CD7), OKT 9+, OKT 10+ and HLA-DR-. Thus, this cell line appears to represent a prothymocyte or stage I thymocyte and preliminary data suggest that it can be induced in vitro to further differentiate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Surface / analysis
  • Cell Line*
  • Female
  • Humans
  • Infant
  • Karyotyping
  • Leukemia, Lymphoid* / genetics
  • Leukemia, Lymphoid* / pathology
  • Translocation, Genetic


  • Antibodies, Monoclonal
  • Antigens, Surface