The Effect of Resveratrol on Blood Glucose and Blood Lipids in Rats with Gestational Diabetes Mellitus

Guanli Zhang; Xiuli Wang; Baofeng Ren; Qiongqiong Zhao; Fang Zhang

doi:10.1155/2021/2956795

The Effect of Resveratrol on Blood Glucose and Blood Lipids in Rats with Gestational Diabetes Mellitus

Evid Based Complement Alternat Med. 2021 Oct 19:2021:2956795. doi: 10.1155/2021/2956795. eCollection 2021.

Authors

Guanli Zhang¹, Xiuli Wang², Baofeng Ren³, Qiongqiong Zhao⁴, Fang Zhang⁵

Affiliations

¹ Department of Obstetrics, Yantaishan Hospital, Yantai 264000, Shandong Province, China.
² Department of Obstetrics, Chengyang People's Hospital, Qingdao 266000, Shandong Province, China.
³ Medical Insurance Department, Zhangqiu District People's Hospital, Jinan,250200, Shandong Province, China.
⁴ Department of Paediatrics (II), Zhangqiu District People's Hospital, Jinan 250200, Shandong Province, China.
⁵ Department of Clinical Laboratory, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, Shandong Province, China.

Abstract

Background: Previous studies have reported that resveratrol has various biological effects such as anti-inflammatory, antioxidant, and antitumor. This study aimed to investigate the effects of resveratrol on blood glucose and blood lipids in rats with gestational diabetes mellitus (GDM).

Methods: The rat diabetes model was prepared by one-time intraperitoneal injection of streptozotocin (STZ, 35 mg/kg). Fasting blood glucose was measured by using a blood glucose meter. The ELISA method was used to detect the levels of insulin, leptin, adiponectin, resistin, TNF-α, and IL-6. The content of TC, TG, LDL-C, and HDL-C was determined by using an automatic biochemical detector.

Results: Compared with the GDM group, the insulin level in the resveratrol (120 and 240 mg/kg) treatment group was significantly increased. But, the blood glucose level and body weight were significantly reduced. The content of TC, TG, and LDL-C in the resveratrol (240 mg/kg) treatment group was significantly reduced, and the content of HDL-C was significantly increased. In addition, leptin, resistin, TNF-α, and IL-6 levels in the 240 mg/kg resveratrol treatment group were significantly reduced, and adiponectin was significantly increased. Also, resveratrol (240 mg/kg) was stronger than metformin hydrochloride in improving insulin secretion and regulating blood lipids and adipokine content.

Conclusion: Resveratrol has a dose-dependent effect on GDM rats to increase insulin secretion, reduce blood glucose and body weight, and regulate blood lipids and plasma adipokines.