Effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation and thromboxane formation

Prostaglandins Leukot Med. 1987 Mar;26(3):241-52. doi: 10.1016/0262-1746(87)90034-5.


The purpose of this study was to test the effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation, thromboxane formation and blood pressure. Fifteen hyperlipidemic males with normal blood pressure were treated for 2 weeks. Resting supine blood pressure, total serum cholesterol, HDL-cholesterol, the ratio of total cholesterol/HDL-cholesterol and triglycerides all were significantly reduced. The maximum aggregation and velocity of aggregation for isolated platelets stimulated with either ADP or collagen was significantly reduced. Thromboxane formation during 5 min of platelet aggregation with collagen or ADP was also significantly reduced. These results have important implications for hypertension and atherosclerotic cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Pressure / drug effects
  • Cholesterol / blood
  • Cholesterol, Dietary / administration & dosage
  • Cholesterol, Dietary / pharmacology*
  • Cholesterol, HDL / blood
  • Dietary Fats / administration & dosage
  • Dietary Fats / pharmacology*
  • Humans
  • Hyperlipidemias / blood*
  • Hyperlipidemias / diet therapy
  • Hyperlipidemias / physiopathology
  • Lipids / blood*
  • Male
  • Middle Aged
  • Platelet Aggregation / drug effects*
  • Thromboxanes / biosynthesis*
  • Triglycerides / blood


  • Cholesterol, Dietary
  • Cholesterol, HDL
  • Dietary Fats
  • Lipids
  • Thromboxanes
  • Triglycerides
  • Cholesterol