Options for preserving fertility in women undergoing gonadotoxic treatment

Cleve Clin J Med. 2021 Nov 2;88(11):607-612. doi: 10.3949/ccjm.88gr.21001.


Cancer chemotherapy and radiotherapy can be toxic to the ovaries, but women can improve their chances of preserving their fertility. Three options are available: gonadotropin-releasing hormone (GnRH) analogues, oocyte cryopreservation, and ovarian tissue cryopreservation. A fourth option, ovarian transposition, is valid for patients undergoing pelvic radiation but is not useful in patients undergoing chemotherapy.

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Cryopreservation
  • Female
  • Fertility
  • Fertility Preservation*
  • Humans
  • Neoplasms* / drug therapy
  • Oocytes
  • Ovary


  • Antineoplastic Agents