m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure

Beijian Zhang; Hao Jiang; Jian Wu; Yun Cai; Zhen Dong; Yongchao Zhao; Qinfeng Hu; Kai Hu; Aijun Sun; Junbo Ge

doi:10.1038/s41392-021-00699-w

m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure

Signal Transduct Target Ther. 2021 Nov 2;6(1):377. doi: 10.1038/s41392-021-00699-w.

Authors

Beijian Zhang^#^{1

2

3

4}, Hao Jiang^#^{1

2

3

4}, Jian Wu^#^{1

2

5}, Yun Cai^{1

2

3

4}, Zhen Dong^{1

2

3

4}, Yongchao Zhao^{1

2

3

4}, Qinfeng Hu^{1

2

5}, Kai Hu^{1

2}, Aijun Sun^{6

7

8

9

10}, Junbo Ge^{11

12

13

14

15}

Affiliations

¹ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
² Shanghai Institute of Cardiovascular Diseases, Shanghai, China.
³ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China.
⁴ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China.
⁵ Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
⁶ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
⁷ Shanghai Institute of Cardiovascular Diseases, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
⁸ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
⁹ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
¹⁰ Institutes of Biomedical Sciences, Fudan University, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
¹¹ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.
¹² Shanghai Institute of Cardiovascular Diseases, Shanghai, China. jbge@zs-hospital.sh.cn.
¹³ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China. jbge@zs-hospital.sh.cn.
¹⁴ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China. jbge@zs-hospital.sh.cn.
¹⁵ Institutes of Biomedical Sciences, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism*
Animals
Glucose / genetics
Glucose / metabolism*
Glycolysis*
Heart Failure / enzymology*
Heart Failure / genetics
Mice

Substances

FTO protein, mouse
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Glucose