Platelet extracellular vesicles in COVID-19: Potential markers and makers

J Leukoc Biol. 2022 Jan;111(1):63-74. doi: 10.1002/JLB.3MIR0221-100R. Epub 2021 Nov 3.


Platelets and platelet extracellular vesicles (pEV) are at the crossroads of coagulation and immunity. Extracellular vesicles are messengers that not only transmit signals between cells, but also provide information about the status of their cell of origin. Thus, pEVs have potential as both biomarkers of platelet activation and contributors to pathology. Coronavirus Disease-19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a complex disease affecting multiple organs and is characterized by a high degree of inflammation and risk of thrombosis in some patients. In this review, we introduce pEVs as valuable biomarkers in disease with a special focus on their potential as predictors of and contributors to COVID-19.

Keywords: HDT; calcium modulators; pCAMKII.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Blood Platelets / metabolism*
  • COVID-19 / metabolism*
  • Extracellular Vesicles / metabolism*
  • Humans
  • Receptors, Virus / metabolism
  • SARS-CoV-2 / physiology*


  • Biomarkers
  • Receptors, Virus