Microvessels enhance vascularization and function of transplanted insulin-producing cells

Alvin C Powers; Marcela Brissova

doi:10.1016/j.cmet.2021.10.013

Microvessels enhance vascularization and function of transplanted insulin-producing cells

Cell Metab. 2021 Nov 2;33(11):2103-2105. doi: 10.1016/j.cmet.2021.10.013.

Authors

Alvin C Powers¹, Marcela Brissova²

Affiliations

¹ Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; VA Tennessee Valley Healthcare System, Nashville, TN 37212, USA. Electronic address: al.powers@vumc.org.
² Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: marcela.brissova@vanderbilt.edu.

PMID: 34731653
DOI: 10.1016/j.cmet.2021.10.013

Abstract

Transplantation of insulin-producing cells is an emerging treatment for type 1 diabetes. A recent report in Cell Stem Cell (Aghazadeh et al., 2021) outlines a new approach that accelerates the engraftment and improves the survival and function of such cell transplants by mixing adipose tissue-derived ready-made microvessels with human pancreatic progenitor cells or cadaveric islets prior to transplantation.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Diabetes Mellitus, Type 1* / therapy
Humans
Insulins*
Islets of Langerhans Transplantation*
Islets of Langerhans*
Microvessels

Substances

Insulins