TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection

BMC Infect Dis. 2021 Nov 3;21(1):1133. doi: 10.1186/s12879-021-06835-9.


Background: Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis C.

Method: The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load.

Results: The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores.

Conclusion: Our results suggest the polymorphic genotype at TNFA -308G>A as protective against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant associated with higher HCV viral load. Further studies must be performed in order to confirm these associations.

Keywords: HCV; Interleukin-10; Polymorphism; TNF-alpha.

MeSH terms

  • Biomarkers
  • Genotype
  • Hepacivirus*
  • Hepatitis C, Chronic* / genetics
  • Humans
  • Interleukin-10 / genetics
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Tumor Necrosis Factor-alpha


  • Biomarkers
  • IL10 protein, human
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • Interleukin-10