Development and evaluation of an early death risk prediction model after acute type A aortic dissection

Yuhui Zhang; Tongyun Chen; Qingliang Chen; Hou Min; Jiang Nan; Zhigang Guo

doi:10.21037/atm-21-4063

Development and evaluation of an early death risk prediction model after acute type A aortic dissection

Ann Transl Med. 2021 Sep;9(18):1442. doi: 10.21037/atm-21-4063.

Authors

Yuhui Zhang^{1

2}, Tongyun Chen², Qingliang Chen², Hou Min³, Jiang Nan², Zhigang Guo²

Affiliations

¹ Clinial College of Chest, Tianjin Medical University, Tianjin, China.
² Department of Cardiovascular Surgery, Tianjin Chest Hospital, Tianjin, China.
³ Clinical Laboratory, Tianjin Chest Hospital, Tianjin, China.

Abstract

Background: The purpose of the study was to assess the relationship between preoperative laboratory examination, clinical imaging data, and postoperative death of patients with acute type A aortic dissection (ATAAD) and to establish a prediction model of hospital death risk after the operation.

Methods: A total of 224 cases of acute Standford A aortic dissection were treated by total arch replacement using a tetrafurcate graft with stented elephant trunk implantation in Tianjin Chest Hospital. Based on preoperative laboratory examination and clinical imaging data of patients with ATAAD, the independent risk factors of postoperative hospital death were obtained using logistic analysis, and a risk prediction model of postoperative hospital death was developed.

Results: Independent risk factors of postoperative death in patients with ATAAD were: body mass index (BMI), preoperative neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), creatinine (Cr), D-dimer, high-sensitive cardiac troponin T (hs-CTnT), apolipoprotein A1, left subclavian artery involvement, and iliac artery involvement. The regression equation of postoperative death risk was: logitP1 = -9.584 + 1.060 × NLR + 1.586 × MPV + 1.009 × Cr + 1.067 × D-dimer + 2.023 × hs-CTnT; the regression equation of postoperative death risk was: logitP2 = -3.296 + 3.242 × left subclavian artery involved + 4.564 × iliac artery involved; the regression equation of postoperative death risk was: logitP3 = -12.864 + 1.149 × BMI + 4.731 × left subclavian artery involved + 4.150 × iliac artery involved + 1.064 × NLR + 1.011 × Cr + 1.084 × D-dimer + 2.242 × hs-CTnT + 3.233 × apolipoprotein A1.

Conclusions: BMI, NLR, MPV, Cr, D-dimer, hs-CTnT, apolipoprotein A1, left subclavian artery involvement and iliac artery involvement can affect the hospital mortality rate of aortic dissection undergoing Sun's operation to varying degrees, which may be helpful to guide the design of the perioperative treatment strategy.

Keywords: Acute type A aortic dissection (ATAAD); postoperative hospital death; prediction of death; risk factors of surgical treatment.