Convergence of adenosine and GABA signaling for synapse stabilization during development

Science. 2021 Nov 5;374(6568):eabk2055. doi: 10.1126/science.abk2055. Epub 2021 Nov 5.

Abstract

[Figure: see text].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / metabolism*
  • Adenosine A2 Receptor Antagonists
  • Adenosine Triphosphate / metabolism
  • Animals
  • Calcium / metabolism
  • Cognition
  • Cyclic AMP / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Hippocampus / growth & development*
  • Hippocampus / metabolism
  • Male
  • Membrane Proteins / metabolism
  • Mice
  • Nerve Tissue Proteins
  • Neurons / physiology*
  • Phosphorylation
  • Receptor, Adenosine A2A / genetics
  • Receptor, Adenosine A2A / metabolism*
  • Receptors, GABA-A / metabolism
  • Signal Transduction*
  • Synapses / physiology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Adenosine A2 Receptor Antagonists
  • Adora2a protein, mouse
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptor, Adenosine A2A
  • Receptors, GABA-A
  • gephyrin
  • gamma-Aminobutyric Acid
  • Adenosine Triphosphate
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases
  • Adenosine
  • Calcium