Lens-vault analysis and its correlation with other biometric parameters using swept-source OCT

J Optom. 2022 Jan-Mar;15(1):88-99. doi: 10.1016/j.optom.2021.04.001. Epub 2021 Nov 1.

Abstract

Purpose: To measure lens vault (LV) and to assess its correlation with various ocular parameters in healthy eyes, using for all measurements the same high-resolution swept-source optical coherence tomographer (SS-OCT).

Methods: We prospectively recruited 67 Caucasian healthy patients whose mean age was 41.9 ± 12.4 years; only their right eye was included in the study. Data were all recorded with the ANTERION SS-OCT and comprised, for each patient, 5 consecutive measurements of LV, anterior chamber depth (ACD), lens thickness (LT), axial length (AL), white-to-white (WTW) distance, central corneal thickness (CCT), anterior chamber volume (ACV) and spur-to-spur (STS) distance.

Results: Mean LV was 0.26 ± 0.23 mm (ranging from -0.24 to 0.78 mm). Data analysis revealed a statistically significant negative correlation between LV and ACD (R=-0.80, p < 0.001), AL (R = -0.36, p = 0.002), and ACV (R = -0.68, p < 0.001), and a positive correlation between LV and LT (R = 0.67, p < 0.001), and age (R = 0.53, p < 0.001). In contrast, no statistically significant correlation was found between LV and WTW (R=-0.17, p = 0.15), CCT (R = 0.11, p = 0.36) or STS (R=-0.10, p = 0.41).

Conclusions: Taking into account our findings about intra-parameter correlation levels, we believe that LV should be measured and analyzed together with other ocular parameters in clinical routine practice both for diagnosis and for some refractive surgeries.

Keywords: Crystalline lens rise; Optical coherence tomography; Spur-to-spur; Swept-source Fourier domain; White-to-white.

MeSH terms

  • Adult
  • Anterior Chamber / anatomy & histology
  • Anterior Chamber / diagnostic imaging
  • Axial Length, Eye
  • Biometry
  • Humans
  • Lens, Crystalline* / anatomy & histology
  • Middle Aged
  • Reproducibility of Results
  • Tomography, Optical Coherence*