Vaccine effectiveness against SARS-CoV-2 transmission to household contacts during dominance of Delta variant (B.1.617.2), the Netherlands, August to September 2021

Euro Surveill. 2021 Nov;26(44):2100977. doi: 10.2807/1560-7917.ES.2021.26.44.2100977.


We estimated SARS-CoV-2 vaccine effectiveness against onward transmission by comparing secondary attack rates among household members for vaccinated and unvaccinated index cases, based on source and contact tracing data collected when the Delta variant was dominant. Effectiveness of full vaccination of the index case against transmission to unvaccinated and fully vaccinated household contacts, respectively, was 63% (95% confidence interval (CI): 46-75) and 40% (95% CI: 20-54), in addition to the direct protection of vaccination of contacts against infection.

Keywords: COVID-19; SARS-CoV-2; household study; transmission; vaccine effectiveness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • Family Characteristics
  • Humans
  • Netherlands / epidemiology
  • SARS-CoV-2
  • Vaccines*


  • COVID-19 Vaccines
  • Vaccines