Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1

Indian J Microbiol. 2021 Dec;61(4):519-523. doi: 10.1007/s12088-021-00957-z. Epub 2021 Jun 20.


Ten compounds (1-10) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resistant pathogenic strains Escherichia coli and Candida albicans with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of C. albicans by eradicating biofilms. Interestingly, the fraction containing 4 presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.

Keywords: Antimicrobial activities; Preliminary mechanisms; Soil-derived fungus.