Obesity and Diabetes

Nurs Clin North Am. 2021 Dec;56(4):527-541. doi: 10.1016/j.cnur.2021.07.008.


Obesity is the most significant risk factor for the development of diabetes. Both obesity and diabetes rates have continued to increase in tandem and pose increased mortality for patients and increased health care costs for the community. Weight loss of 5% or more of total body weight renders improvements in glycemic control, decreases in the need for diabetes medications, and improved quality of life. Cotreatment of obesity and diabetes requires a comprehensive medical approach that encompasses intensive lifestyle modification including behavioral changes, nutrition, and physical activity, as well as pharmacotherapy and possible surgical management.

Keywords: Antihyperglycemic pharmacotherapy; Antiobesity pharmacotherapy; Intensive lifestyle modification; Overweight and obesity; Surgical treatment for obesity and diabetes; Type 2 diabetes; Weight centric approach to the treatment of diabetes.

Publication types

  • Review

MeSH terms

  • Behavior Therapy*
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Exercise*
  • Gastric Bypass
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Life Style
  • Metformin / therapeutic use*
  • Obesity / drug therapy*
  • Obesity / epidemiology
  • Obesity / physiopathology*
  • Risk Factors
  • Weight Loss*


  • Hypoglycemic Agents
  • Metformin