The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone

Dermatol Online J. 2021 Aug 15;27(8). doi: 10.5070/D327854686.

Abstract

Objective: Combination topical clotrimazole/ betamethasone dipropionate (C-BM) contains a high-potency topical corticosteroid and is not infrequently prescribed for inappropriate patient groups and body sites. Use of C-BM can lead to inadequate clearance or exacerbation of fungal infections as well as cutaneous atrophy, striae, and other skin maladies.

Methods: We performed a retrospective chart review of 1,978 clinical visits where C-BM was prescribed within the University of Utah Health system between 2014 and 2018 to better understand current prescribing patterns.

Results: 1,974 prescriptions were written for C-BM. 91.6% of patients were at least the recommended age of 17 years. C-BM was most commonly prescribed for rashes of an inflammatory (42.2%) or fungal nature (38.1%). Clotrimazole/betamethasone dipropionate was prescribed for sensitive areas (face, axillae, groin or diaper region) in 48.9% of patients. Family medicine clinicians prescribed 58.3% of C-BM prescriptions, whereas dermatology clinicians accounted for 3.4%.

Conclusion: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.

MeSH terms

  • Adolescent
  • Adult
  • Antifungal Agents / therapeutic use*
  • Betamethasone / analogs & derivatives*
  • Betamethasone / therapeutic use
  • Child
  • Clotrimazole / therapeutic use*
  • Drug Combinations
  • Female
  • Glucocorticoids / therapeutic use*
  • Humans
  • Logistic Models
  • Male
  • Mycoses / drug therapy*
  • Prescription Drug Overuse / statistics & numerical data*
  • Retrospective Studies

Substances

  • Antifungal Agents
  • Drug Combinations
  • Glucocorticoids
  • betamethasone-17,21-dipropionate
  • Betamethasone
  • Clotrimazole