COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

Int J Infect Dis. 2022 Jan:114:178-182. doi: 10.1016/j.ijid.2021.10.045. Epub 2021 Oct 29.


This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

Keywords: Case report; Immunocompromised; Mutation; SARS-CoV-2; Sequencing; Viral culture.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19*
  • Female
  • Humans
  • Immunocompromised Host
  • Mutation
  • SARS-CoV-2*
  • Virus Shedding
  • Young Adult