SPRINT Revisited: Updated Results and Implications

Jackson T Wright Jr; Paul K Whelton; Karen C Johnson; Joni K Snyder; David M Reboussin; William C Cushman; Jeff D Williamson; Nicholas M Pajewski; Alfred K Cheung; Cora E Lewis; Suzanne Oparil; Michael V Rocco; Srinivasan Beddhu; Lawrence J Fine; Jeffrey A Cutler; Walter T Ambrosius; Mahboob Rahman; Carolyn H Still; Zhengyi Chen; Curtis Tatsuoka; SPRINT Research Group

doi:10.1161/HYPERTENSIONAHA.121.17682

SPRINT Revisited: Updated Results and Implications

Hypertension. 2021 Dec;78(6):1701-1710. doi: 10.1161/HYPERTENSIONAHA.121.17682. Epub 2021 Nov 10.

Authors

Jackson T Wright Jr¹, Paul K Whelton², Karen C Johnson³, Joni K Snyder⁴, David M Reboussin⁵, William C Cushman³, Jeff D Williamson⁶, Nicholas M Pajewski⁵, Alfred K Cheung⁷, Cora E Lewis⁸, Suzanne Oparil⁹, Michael V Rocco¹⁰, Srinivasan Beddhu⁷, Lawrence J Fine⁴, Jeffrey A Cutler⁴, Walter T Ambrosius⁵, Mahboob Rahman¹, Carolyn H Still¹¹, Zhengyi Chen¹², Curtis Tatsuoka¹²; SPRINT Research Group

Affiliations

¹ From the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH.
² Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana (P.K.W.).
³ Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.).
⁴ Clinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
⁵ Department of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.
⁶ Section of Gerontology and Geriatric Medicine (J.D.W.), Wake Forest School of Medicine, Winston-Salem, NC.
⁷ Renal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.).
⁸ Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C., S.B.).
⁹ Department of Epidemiology (C.E.L.), University of Alabama at Birmingham.
¹⁰ Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.
¹¹ Frances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH.
¹² Department of Medicine (S.O.), University of Alabama at Birmingham.

Abstract

The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this article is to respond to key questions that have been raised.

Keywords: blood pressure; cardiovascular disease; controlled clinical trial; heart failure; hypertension; myocardial infarction.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Blood Pressure / physiology
Humans
Hypertension / drug therapy*
Hypertension / physiopathology
Randomized Controlled Trials as Topic*
Treatment Outcome

Substances

Antihypertensive Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding