Coagulation and immunity: Caught in the fibrin web

Elif G Sozmen; Katerina Akassoglou

doi:10.1016/j.immuni.2021.10.016

Coagulation and immunity: Caught in the fibrin web

Immunity. 2021 Nov 9;54(11):2439-2441. doi: 10.1016/j.immuni.2021.10.016.

Authors

Elif G Sozmen¹, Katerina Akassoglou²

Affiliations

¹ Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA.
² Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA. Electronic address: kakassoglou@gladstone.ucsf.edu.

Abstract

In this issue of Immunity, Vega-Pérez et al. (2021) reveal the formation of a dynamic multicellular aggregate within a fibrin scaffold consisting of large peritoneal macrophages, B1 cells, neutrophils, and monocytes during antibacterial immunity in the peritoneum. Anticoagulants targeting thrombin or peritoneal macrophage depletion by clodronate impaired efficient control of E. coli infection.

Publication types

Comment

MeSH terms

Animals
Blood Coagulation
Escherichia coli*
Fibrin*
Mice
Mice, Inbred C57BL
Monocytes

Substances

Fibrin

Abstract

Publication types

MeSH terms

Substances

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