Rosai-Dorfman disease of thymus with elevated serum anti-acetylcholine receptor antibody: a case report

Ryusuke Tsujimura; Daisuke Sato; Hiyo Obikane; Riken Kawachi; Masahiko Sugitani; Hiroyuki Hao; Hiroyuki Sakurai; Mitsunori Yamakawa; Shinobu Masuda

Rosai-Dorfman disease of thymus with elevated serum anti-acetylcholine receptor antibody: a case report

Int J Clin Exp Pathol. 2021 Oct 15;14(10):1061-1064. eCollection 2021.

Authors

Ryusuke Tsujimura¹, Daisuke Sato^{2

3}, Hiyo Obikane^{1

4}, Riken Kawachi², Masahiko Sugitani^{1

5}, Hiroyuki Hao¹, Hiroyuki Sakurai², Mitsunori Yamakawa⁶, Shinobu Masuda¹

Affiliations

¹ Department of Pathology, Nihon University School of Medicine Tokyo, Japan.
² Department of Respiratory Surgery, Nihon University School of Medicine Tokyo, Japan.
³ Second Department of Surgery, Faculty of Medicine, University of Yamanashi Yamanashi, Japan.
⁴ Department of Diagnostic Pathology, Tokyo Metropolitan Police Hospital Tokyo, Japan.
⁵ Pathology Division, Ageo Central General Hospital Saitama, Japan.
⁶ Department of Pathological Diagnostics, Yamagata University Faculty of Medicine Yamagata, Japan.

PMID: 34760043
PMCID: PMC8569306

Abstract

Rosai-Dorfman disease is a rare disorder of histiocytic proliferation in lymph nodes and at extranodal sites. We herein describe a patient with isolated Rosai-Dorfman disease in the thymus with elevated anti-acetylcholine receptor antibody. We examined the relationship between Rosai-Dorfman disease and elevated anti-acetylcholine receptor antibody. To our knowledge, elevated anti-acetylcholine receptor antibody has not been reported in isolated thymic Rosai-Dorfman disease.

Keywords: Rosai-Dorfman disease; anti-acetylcholine receptor antibody; thymus.

Publication types

Case Reports