Prenylated xanthones with α-glucosidase and α-amylase inhibitory effects from the pericarp of Garcinia mangostana

J Asian Nat Prod Res. 2022 Jul;24(7):624-633. doi: 10.1080/10286020.2021.1967328. Epub 2021 Nov 11.

Abstract

Two new prenylated xanthones, mangoxanthones A-B (1-2), together with four known compounds 3-6, were isolated from the ethanol extract of the pericarp of Garcinia mangostana. The structures of these compounds have been elucidated based on spectroscopic analysis. The analysis results of chiral HPLC revealed compounds 1 and 2 were scalemic mixtures respectively. All isolated compounds were biologically evaluated for their α-glucosidase and α-amylase inhibitory effects using in-vitro assays. Compound 1 showed moderate inhibitory activities against α-glucosidase and α-amylase with IC50 of 29.06 ± 1.86 and 22.74 ± 2.07 μM, respectively. Molecular docking predicted the binding sites of compound 1 to α-glucosidase and α-amylase. A preliminary structure-activity relationship was discussed.

Keywords: Clusiaceae; Garcinia mangostana; mangoxanthones; xanthones; α-amylase inhibition; α-glucosidase inhibition.

MeSH terms

  • Fruit / chemistry
  • Garcinia mangostana* / chemistry
  • Garcinia*
  • Molecular Docking Simulation
  • Molecular Structure
  • Xanthones* / chemistry
  • Xanthones* / pharmacology
  • alpha-Amylases / analysis
  • alpha-Glucosidases

Substances

  • Xanthones
  • alpha-Amylases
  • alpha-Glucosidases