Molecular Self-Assembly as a Tool to Construct Transmembrane Supramolecular Ion Channels

Chem Rec. 2022 Feb;22(2):e202100225. doi: 10.1002/tcr.202100225. Epub 2021 Nov 12.


Self-assembly has become a powerful tool for building various supramolecular architectures with applications in material science, environmental science, and chemical biology. One such area is the development of artificial transmembrane ion channels that mimic naturally occurring channel-forming proteins to unveil various structural and functional aspects of these complex biological systems, hoping to replace the defective protein channels with these synthetically accessible moieties. This account describes our recent approaches to construct supramolecular ion channels using synthetic molecules and their applications in medicinal chemistry.

Keywords: Apoptosis; Ion channel; Ion transport; Self-assembly; Stimulus responsive.

Publication types

  • Review

MeSH terms

  • Ion Channels* / chemistry


  • Ion Channels