Emerging Role of Non-coding RNAs in Autism Spectrum Disorder

Soudeh Ghafouri-Fard; Rezvan Noroozi; Serge Brand; Bashdar Mahmud Hussen; Reyhane Eghtedarian; Mohammad Taheri; Kaveh Ebrahimzadeh

doi:10.1007/s12031-021-01934-3

Emerging Role of Non-coding RNAs in Autism Spectrum Disorder

J Mol Neurosci. 2022 Feb;72(2):201-216. doi: 10.1007/s12031-021-01934-3. Epub 2021 Nov 12.

Authors

Soudeh Ghafouri-Fard¹, Rezvan Noroozi², Serge Brand³, Bashdar Mahmud Hussen⁴, Reyhane Eghtedarian⁵, Mohammad Taheri^{6

7}, Kaveh Ebrahimzadeh⁸

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
³ Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, University of Basel, Basel, Switzerland.
⁴ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
⁵ Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad_823@yahoo.com.
⁷ Institute of Human Genetics, Jena University Hospital, 07740, Jena, Germany. mohammad_823@yahoo.com.
⁸ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dr.kavehmay1980@gmail.com.

PMID: 34767189
DOI: 10.1007/s12031-021-01934-3

Abstract

Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2-AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.

Keywords: Autism spectrum disorder; circRNA; lncRNA; miRNA.

Publication types

Review

MeSH terms

Autism Spectrum Disorder* / genetics
Autism Spectrum Disorder* / metabolism
Humans
Phosphatidylinositol 3-Kinases
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding