Emerging Role of Non-coding RNAs in Autism Spectrum Disorder

J Mol Neurosci. 2022 Feb;72(2):201-216. doi: 10.1007/s12031-021-01934-3. Epub 2021 Nov 12.


Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2-AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.

Keywords: Autism spectrum disorder; circRNA; lncRNA; miRNA.

Publication types

  • Review

MeSH terms

  • Autism Spectrum Disorder* / genetics
  • Autism Spectrum Disorder* / metabolism
  • Humans
  • Phosphatidylinositol 3-Kinases
  • RNA, Long Noncoding* / genetics


  • RNA, Long Noncoding