A lymphocyte-glia connection sets the pace for smoldering inflammation

Stefan Bittner; Frauke Zipp

doi:10.1016/j.cell.2021.10.018

A lymphocyte-glia connection sets the pace for smoldering inflammation

Cell. 2021 Nov 11;184(23):5696-5698. doi: 10.1016/j.cell.2021.10.018.

Authors

Stefan Bittner¹, Frauke Zipp²

Affiliations

¹ Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
² Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address: zipp@uni-mainz.de.

PMID: 34767775
DOI: 10.1016/j.cell.2021.10.018

Abstract

Successful therapeutic options directly targeting disability progression in patients with multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system, are lacking. Now, a study published in Nature by Absinta and colleagues profiles a lymphocyte-glia connection at the edge of chronic active lesions that continuously drives neurodegenerative pathways.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Central Nervous System
Humans
Inflammation
Lymphocytes
Multiple Sclerosis*
Neuroglia