A lymphocyte-glia connection sets the pace for smoldering inflammation

Cell. 2021 Nov 11;184(23):5696-5698. doi: 10.1016/j.cell.2021.10.018.


Successful therapeutic options directly targeting disability progression in patients with multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system, are lacking. Now, a study published in Nature by Absinta and colleagues profiles a lymphocyte-glia connection at the edge of chronic active lesions that continuously drives neurodegenerative pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Central Nervous System
  • Humans
  • Inflammation
  • Lymphocytes
  • Multiple Sclerosis*
  • Neuroglia