Acute Large Vessel Ischemic Stroke in Patients With COVID-19-Related Multisystem Inflammatory Syndrome

Pediatr Neurol. 2022 Jan:126:104-107. doi: 10.1016/j.pediatrneurol.2021.09.013. Epub 2021 Sep 25.

Abstract

Background: Acute ischemic stroke (AIS) is rare in children, and diagnosis is often delayed. Neurological involvement may occur in multisystem inflammatory syndrome in children (MIS-C), but very few cases of AIS in patients with MIS-C have been reported.

Patient descriptions: We two patients with AIS presenting with large vessel occlusive disease in previously healthy adolescents recently exposed to SARS-CoV-2 infection.

Results: Both patients were subsequently diagnosed with and treated for MIS-C. Here, we discuss the course of their treatments and clinical responses.

Conclusion: Early recognition and diagnosis of AIS with large vessel occlusion in children with MIS-C is critical to make available all treatment options to improve clinical outcomes.

Keywords: Acute ischemic infarction; COVID-19; Large vessel; MIS-C; SARS-Cov2; Stroke.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • COVID-19 / complications*
  • COVID-19 / diagnosis
  • COVID-19 / therapy
  • Female
  • Humans
  • Ischemic Stroke / diagnosis*
  • Ischemic Stroke / therapy
  • Ischemic Stroke / virology*
  • Systemic Inflammatory Response Syndrome / complications*
  • Systemic Inflammatory Response Syndrome / diagnosis*
  • Systemic Inflammatory Response Syndrome / therapy

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related