The erg gene: a human gene related to the ets oncogene

Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5. doi: 10.1073/pnas.84.17.6131.


We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4.6 kilobases long) revealed that this gene encodes a 363-residue protein whose predicted amino acid sequence showed a homology of approximately equal to 40% and approximately equal to 70% to two domains corresponding to the 5' and 3' regions of v-ets oncogene, respectively. A 3.2- to 3.6-kilobase and approximately equal to 5-kilobase transcript of the erg gene, which differ in size from those of the previously described Hu-ets 1 and Hu-ets 2 genes, were observed in different cells. These results suggest that the erg gene is a member of the ets oncogene family.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • DNA / genetics
  • DNA-Binding Proteins*
  • Humans
  • Molecular Sequence Data
  • Oncogene Proteins / genetics
  • Oncogenes*
  • Trans-Activators*
  • Transcription Factors*
  • Transcription, Genetic
  • Transcriptional Regulator ERG


  • DNA-Binding Proteins
  • ERG protein, human
  • Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • Transcriptional Regulator ERG
  • DNA

Associated data

  • GENBANK/M17390
  • GENBANK/M21535
  • GENBANK/M21536