Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivity

Phytochemistry. 2022 Jan;193:113011. doi: 10.1016/j.phytochem.2021.113011. Epub 2021 Nov 11.


Metabolites from fungi are a major source of natural small molecule drugs in addition to plants, while fungal derived terpenoids have been confirmed to have great potentials in many diseases. Aspergillus fungi are distributed in every corner of the earth, and their terpenoid metabolites exhibit promising diversity in term of both their chemistry and bioactivity. This review attempted to provide timely and comprehensive coverage of chemical, biosynthesis, and biological studies on terpenoids discovered from the genus Aspergillus, including mono-, sesqui-, di-, sester-, tri-, and meroterpenoids, in the last decade. The structural characteristics, biosynthesis, and pharmacological activities of 288 terpenoids were introduced.

Keywords: Biological activity; Biosynthesis; Genus Aspergillus; Terpenoids; Trichocomaceae.

Publication types

  • Review

MeSH terms

  • Aspergillus
  • Biological Products* / pharmacology
  • Fungi
  • Plants
  • Terpenes*


  • Biological Products
  • Terpenes