Post-COVID-19 vaccination IgA vasculitis in an adult

J Cutan Pathol. 2022 Apr;49(4):385-387. doi: 10.1111/cup.14168. Epub 2021 Nov 30.

Abstract

Leukocytoclastic vasculitis has been reported in the setting of COVID-19 infection and post-COVID-19 vaccination. We report a case of IgA vasculitis (IgAV) post-COVID-19 vaccination, with immunoglobulin A (IgA) immune deposits in the skin and renal involvement. SARS-CoV spike protein immunohistochemical staining was negative. IgAV with skin and renal involvement is a potential reaction to COVID-19 vaccination.

Keywords: COVID vaccine; Henoch-Schönlein purpura; IgA vasculitis; leukocytoclastic vasculitis; palpable purpura.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • COVID-19 Vaccines / adverse effects*
  • Drug-Related Side Effects and Adverse Reactions / complications
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Drug-Related Side Effects and Adverse Reactions / physiopathology
  • Humans
  • IgA Vasculitis / etiology*
  • IgA Vasculitis / pathology
  • Immunohistochemistry / methods
  • Male

Substances

  • COVID-19 Vaccines