Imaging and dosimetry for alpha-particle emitter radiopharmaceutical therapy: improving radiopharmaceutical therapy by looking into the black box

George Sgouros; Eric Frey; Yong Du; Rob Hobbs; Wesley Bolch

doi:10.1007/s00259-021-05583-x

Imaging and dosimetry for alpha-particle emitter radiopharmaceutical therapy: improving radiopharmaceutical therapy by looking into the black box

Eur J Nucl Med Mol Imaging. 2021 Dec;49(1):18-29. doi: 10.1007/s00259-021-05583-x. Epub 2021 Nov 16.

Authors

George Sgouros¹, Eric Frey², Yong Du², Rob Hobbs², Wesley Bolch²

Affiliations

¹ Johns Hopkins University, Baltimore, MD, USA. gsgouros@jhmi.edu.
² Johns Hopkins University, Baltimore, MD, USA.

PMID: 34782911
DOI: 10.1007/s00259-021-05583-x

Abstract

Radiopharmaceutical therapy using α-particle emitting radionuclides (αRPT) is a novel treatment modality that delivers highly potent alpha-particles to cancer cells or their environment. We review the advantages and challenges of imaging and dosimetry in implementing αRPT for cancer patients.

Keywords: Alpha-particle emitter; Black box; Dosimetry; Radiopharmaceutical therapeutics.

Publication types

Review

MeSH terms

Alpha Particles / therapeutic use
Humans
Neoplasms* / diagnostic imaging
Neoplasms* / radiotherapy
Radioisotopes
Radiometry
Radiopharmaceuticals* / therapeutic use

Substances

Radioisotopes
Radiopharmaceuticals