New Heights for ProTides?

J Med Chem. 2021 Nov 25;64(22):16422-16424. doi: 10.1021/acs.jmedchem.1c01908. Epub 2021 Nov 16.


In this issue of the Journal of Medicinal Chemistry, Janeba et al. found that the in vitro antiviral activity and selectivity index of the aryloxy phosphoramidate (ProTide) prodrug of the acyclic nucleoside phosphonate tenofovir (tenofovir alafenamide) can be dramatically improved by replacing the aryloxy pro-moiety with an appropriate tyrosine derivative. This Viewpoint highlights the possible impact and ramifications that these findings may have in the development of new ProTides.

Publication types

  • Comment

MeSH terms

  • Antiviral Agents
  • Chemistry, Pharmaceutical
  • Nucleosides
  • Organophosphonates*
  • Prodrugs*


  • Antiviral Agents
  • Nucleosides
  • Organophosphonates
  • Prodrugs