Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment

Penelope Kallis; Elizabeth Bisbee; Cheryl Garganta; Jennifer J Schoch

doi:10.1111/pde.14865

Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment

Pediatr Dermatol. 2022 Jan;39(1):151-152. doi: 10.1111/pde.14865. Epub 2021 Nov 17.

Authors

Penelope Kallis¹, Elizabeth Bisbee¹, Cheryl Garganta², Jennifer J Schoch¹

Affiliations

¹ Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA.
² Division of Genetics, Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.

PMID: 34787337
DOI: 10.1111/pde.14865

Abstract

Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disorder of cholesterol synthesis characterized by unilateral ichthyosiform dermatitis with ipsilateral limb hypoplasia. Recently, pathogenesis-based treatment has demonstrated improvement of skin lesions with statins by decreasing formation of cholesterol intermediates through inhibition of cholesterol synthesis. We report a 10-month-old girl who presented with unilateral scaly ptychotropic plaques, who experienced rapid, near-complete clearance with topical 5% simvastatin monotherapy twice daily.

Keywords: CHILD syndrome; drug therapy; ichthyosis; simvastatin; statin.

MeSH terms

Abnormalities, Multiple
Female
Genetic Diseases, X-Linked
Humans
Ichthyosiform Erythroderma, Congenital* / drug therapy
Infant
Limb Deformities, Congenital*
Ointments
Simvastatin / therapeutic use

Substances

Ointments
Simvastatin

Supplementary concepts

Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects