Extended wear of contact lenses can compromise corneal epithelial adhesion

Curr Eye Res. 1987 Oct;6(10):1257-60. doi: 10.3109/02713688709025236.


The wound healing response of the cat corneal epithelium was examined to provide information on the effect of extended wear contact lenses on epithelial integrity. During the wounding procedure, a loss of epithelial adhesion in the lens wearing eye relative to the control eye was noted. This indicates a loss of epithelium-to-basement membrane adhesion which may be a result of contact-lens induced hypoxia.

MeSH terms

  • Animals
  • Cats
  • Contact Lenses, Extended-Wear / adverse effects*
  • Contact Lenses, Hydrophilic / adverse effects*
  • Cornea / physiology*
  • Epithelium / physiology
  • Wound Healing