Emerging trends in nanoparticle toxicity and the significance of using Daphnia as a model organism

Abstract

Nanoparticle production is on the rise due to its many uses in the burgeoning nanotechnology industry. Although nanoparticles have growing applications, there is great concern over their environmental impact due to their inevitable release into the environment. With uncertainty of environmental concentration and risk to aquatic organisms, the microcrustacean Daphnia spp. has emerged as an important freshwater model organism for risk assessment of nanoparticles because of its biological properties, including parthenogenetic reproduction; small size and short generation time; wide range of endpoints for ecotoxicological studies; known genome, useful for providing mechanistic information; and high sensitivity to environmental contaminants and other stressors. In this review, we (1) highlight the advantages of using Daphnia as an experimental model organism for nanotoxicity studies, (2) summarize the impacts of nanoparticle physicochemical characteristics on toxicity in relation to Daphnia, and (3) summarize the effects of nanoparticles (including nanoplastics) on Daphnia as well as mechanisms of toxicity, and (4) highlight research uncertainties and recommend future directions necessary to develop a deeper understanding of the fate and toxicity of nanoparticles and for the development of safer and more sustainable nanotechnology.

Keywords: Crustacean; Ecotoxicology; Nanotechnology; Nanotoxicology; Review; Zooplankton.