Pediatric Malaria: Global and North American Perspectives

Ella M E Forgie; Hannah M Brooks; Michelle Barton; Michael T Hawkes

doi:10.1016/j.pcl.2021.08.008

Pediatric Malaria: Global and North American Perspectives

Pediatr Clin North Am. 2022 Feb;69(1):47-64. doi: 10.1016/j.pcl.2021.08.008.

Authors

Ella M E Forgie¹, Hannah M Brooks², Michelle Barton³, Michael T Hawkes⁴

Affiliations

¹ Department of Anthropology, University of Alberta, Tory Building, 11211 Saskatchewan Drive, Edmonton, Alberta T6G 2H4, Canada.
² Faculty of Nursing, University of Alberta, 5-143 Edmonton Clinic Health Academy, 11405 87 Avenue Northwest, Edmonton, Alberta T6G 1C9, Canada.
³ Department of Paediatrics, Division of Pediatric Infectious Diseases, Schulich School of Medicine, Western University, Children's Health Research Institute, Lawson Health Research Institute, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 5W9, Canada.
⁴ Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Clinic Health Academy, 11405 87 Avenue Northwest, Edmonton, Alberta T6G 1C9, Canada; Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Clinic Health Academy, 11405 87 Avenue Northwest, Edmonton, Alberta T6G 1C9, Canada; School of Public Health, University of Alberta, Edmonton Clinic Health Academy, 11405 87 Avenue Northwest, Edmonton, Alberta T6G 1C9, Canada; Women and Children's Health Research Institute, Edmonton, Canada. Electronic address: mthawkes@ualberta.ca.

PMID: 34794676
DOI: 10.1016/j.pcl.2021.08.008

Abstract

Malaria is a leading cause of death in children less than 5 years of age globally, and a common cause of fever in the returning North American traveler. New tools in the fight against malaria have been developed over the past decades: potent artemisinin derivatives; rapid diagnostic tests; long-lasting insecticidal bed nets; and a new vaccine, RTS,S/AS01. Thwarting these advances, parasite and Anopheles vector resistance are emerging. In the meantime, clinicians will continue to see malaria among febrile travelers from the tropics. Early recognition, diagnosis, and treatment can be lifesaving, but rely on the vigilance of frontline clinicians.

Keywords: Artemether-lumefantrine; Artesunate; Children; Malaria; North America.

Publication types

Review

MeSH terms

Acute Kidney Injury / epidemiology
Anemia / epidemiology
Antimalarials / therapeutic use
Artemether, Lumefantrine Drug Combination / therapeutic use
Artemisinins / therapeutic use
Artesunate / therapeutic use
Child
Child, Preschool
Female
Global Health*
Humans
Infant
Malaria / diagnosis
Malaria / drug therapy*
Malaria / epidemiology*
Malaria / prevention & control
Male
North America
Plasmodium / isolation & purification
Respiratory Distress Syndrome / epidemiology
Travel

Substances

Antimalarials
Artemether, Lumefantrine Drug Combination
Artemisinins
Artesunate
artemisinin