Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases

Ira Milosevic; Michael A Cousin

doi:10.1083/jcb.202111056

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases

J Cell Biol. 2021 Dec 6;220(12):e202111056. doi: 10.1083/jcb.202111056. Epub 2021 Nov 19.

Authors

Ira Milosevic^{1

2}, Michael A Cousin^{3

4

5}

Affiliations

¹ Wellcome Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, Oxford, UK.
² University of Coimbra, Multidisciplinary Institute of Ageing, Coimbra, Portugal.
³ Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁴ Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK.
⁵ Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.

Abstract

The regulation of activity-dependent bulk endocytosis, the dominant mode of membrane retrieval in response to intense neuronal activity, is poorly understood. In this JCB issue, Peng et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202011028) propose a novel molecular mechanism for the coordination of activity-dependent bulk endocytosis that builds on Minibrain kinase and its presynaptic substrate synaptojanin-1.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Endocytosis*
Phosphoric Monoester Hydrolases* / genetics

Substances

Phosphoric Monoester Hydrolases

Abstract

Publication types

MeSH terms

Substances

Grants and funding