Colorectal Cancer Screening Recommendations and Outcomes in Lynch Syndrome

Christine Drogan; Sonia S Kupfer

doi:10.1016/j.giec.2021.08.001

Colorectal Cancer Screening Recommendations and Outcomes in Lynch Syndrome

Gastrointest Endosc Clin N Am. 2022 Jan;32(1):59-74. doi: 10.1016/j.giec.2021.08.001.

Authors

Christine Drogan¹, Sonia S Kupfer²

Affiliations

¹ Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA.
² Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: skupfer@medicine.bsd.uchicago.edu.

PMID: 34798987
DOI: 10.1016/j.giec.2021.08.001

Abstract

Screening for colorectal cancer (CRC) in Lynch syndrome enables early detection and likely cancer prevention. CRC screening guidelines have evolved from universal to gene-specific recommendations based on lifetime neoplasia risks. Regular screening for Lynch syndrome reduces CRC-related mortality; however, high CRC incidence during regular colonoscopy screening suggests the possibility of nonpolypoid carcinogenesis. Colonoscopy is the primary modality for screening for Lynch syndrome with mixed and emerging data on quality metrics, chromoendoscopy, artificial intelligence, and nonendoscopic modalities. Screening adherence varies across studies. In this review, we present the current state of CRC screening recommendations, outcomes, and modalities in Lynch syndrome.

Keywords: Artificial intelligence; Chromoendoscopy; Colorectal cancer; Lynch syndrome; Quality; Screening.

Publication types

Review

MeSH terms

Artificial Intelligence
Colonoscopy
Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms, Hereditary Nonpolyposis* / diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
Early Detection of Cancer
Humans