Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer

Gastrointest Endosc Clin N Am. 2022 Jan;32(1):75-93. doi: 10.1016/j.giec.2021.08.002.


Lynch syndrome (LS) is a common form of inherited cancer susceptibility, which predisposes to colorectal cancer (CRC) along with a wide array of other extracolonic malignancies, including other gastrointestinal cancers, cancers of the gynecologic and genitourinary tracts, and other organ sites. Recent data have provided novel insights into patient-specific factors that can help clinicians understand an individual LS carrier's risk of extracolonic cancers, including sex, specific LS gene, age, family history of cancer, and other factors. This summary seeks to provide an update on extracolonic cancer risks in LS and provide recommendations for surveillance and risk reduction.

Keywords: Extra-colonic; HNPCC; Screening.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms* / epidemiology
  • Colorectal Neoplasms* / etiology
  • Colorectal Neoplasms, Hereditary Nonpolyposis* / complications
  • Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Surveys and Questionnaires