BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

J Hepatol. 2022 Mar;76(3):681-693. doi: 10.1016/j.jhep.2021.11.018. Epub 2021 Nov 19.


There have been major advances in the armamentarium for hepatocellular carcinoma (HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and treatment strategy published in 2018. Whilst there have been advances in all areas, we will focus on those that have led to a change in strategy and we will discuss why, despite being encouraging, data for select interventions are still too immature for them to be incorporated into an evidence-based model for clinicians and researchers. Finally, we describe the critical insight and expert knowledge that are required to make clinical decisions for individual patients, considering all of the parameters that must be considered to deliver personalised clinical management.

Keywords: AFP; ALBI score; BCLC; HCC; TARE; ablation; liver transplantation TACE; surgery; survival; systemic treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / classification*
  • Carcinoma, Hepatocellular / complications
  • Female
  • Humans
  • Liver Neoplasms / classification
  • Liver Neoplasms / complications
  • Male
  • Middle Aged
  • Neoplasm Staging / methods
  • Neoplasm Staging / statistics & numerical data
  • Prognosis*
  • Severity of Illness Index