Clinical Replacement Strategies for Meniscus Tissue Deficiency

Cartilage. 2021 Dec;13(1_suppl):262S-270S. doi: 10.1177/19476035211060512. Epub 2021 Nov 20.


Meniscus tissue deficiency resulting from primary meniscectomy or meniscectomy after failed repair is a clinical challenge because the meniscus has little to no capacity for regeneration. Loss of meniscus tissue has been associated with early-onset knee osteoarthritis due to an increase in joint contact pressures in meniscectomized knees. Clinically available replacement strategies range from allograft transplantation to synthetic implants, including the collagen meniscus implant, ACTIfit, and NUSurface. Although short-term efficacy has been demonstrated with some of these treatments, factors such as long-term durability, chondroprotective efficacy, and return to sport activities in young patients remain unpredictable. Investigations of cell-based and tissue-engineered strategies to treat meniscus tissue deficiency are ongoing.

Keywords: meniscus; meniscus augmentation; meniscus transplantation; procedures; tissue.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Allografts
  • Collagen / therapeutic use*
  • Humans
  • Knee Joint
  • Meniscectomy / adverse effects*
  • Menisci, Tibial / surgery
  • Meniscus / surgery*
  • Osteoarthritis, Knee / etiology
  • Postoperative Complications
  • Tibial Meniscus Injuries / surgery*
  • Tissue Engineering
  • Transplantation


  • Collagen