Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia

Shubao Wei; Xiuqiong Chen; Yousheng Xiao; Wenyan Jiang; Qiong Yin; Chunhui Lu; Lu Yang; Jing Wei; Yang Liu; Wenmei Li; Jingqun Tang; Wenbin Guo; Shuguang Luo

doi:10.3389/fneur.2021.729068

Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia

Front Neurol. 2021 Nov 5:12:729068. doi: 10.3389/fneur.2021.729068. eCollection 2021.

Authors

Shubao Wei¹, Xiuqiong Chen¹, Yousheng Xiao², Wenyan Jiang², Qiong Yin², Chunhui Lu², Lu Yang², Jing Wei², Yang Liu², Wenmei Li³, Jingqun Tang², Wenbin Guo⁴, Shuguang Luo²

Affiliations

¹ Department of Rehabilitation Medicine, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
² Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
³ Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
⁴ National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.

Abstract

Background: Increasing evidence from modern neuroimaging has confirmed that cervical dystonia (CD) is caused by network abnormalities. Specific brain networks are known to be crucial in patients suffering from CD. However, changes in network homogeneity (NH) in CD patients have not been characterized. Therefore, the purpose of this study was to investigate the NH of patients with CD. Methods: An automated NH method was used to analyze resting-state functional magnetic resonance (fMRI) data from 19 patients with CD and 21 gender- and age-matched healthy controls (HC). Correlation analysis were conducted between NH, illness duration and symptom severity measured by the Tsui scale. Results: Compared with the HC group, CD patients showed a lower NH in the right superior medial frontal gyrus. No significant correlations were found between abnormal NH values and illness duration or symptom severity. Conclusion: Our findings suggest the existence of abnormal NH in the default mode network (DMN) of CD patients, and thereby highlight the importance of the DMN in the pathophysiology of CD.

Keywords: cervical dystonia; default mode network; network homogeneity; resting-state functional magnetic resonance; superior medial frontal gyrus.