Detection and predictors of anti-SARS-CoV-2 antibody levels in COVID-19 patients at 8 months after symptom onset

Jing Guo; Li Li; Qian Wu; Hongwei Li; Yajie Li; Xinwei Hou; Fangfei Yang; Zhonghua Qin

doi:10.2217/fvl-2021-0141

Detection and predictors of anti-SARS-CoV-2 antibody levels in COVID-19 patients at 8 months after symptom onset

Future Virol. 2021 Oct;0(0):10.2217/fvl-2021-0141. doi: 10.2217/fvl-2021-0141. Epub 2021 Nov 12.

Authors

Jing Guo^{1

2}, Li Li^{1

2}, Qian Wu^{1

2}, Hongwei Li^{1

2}, Yajie Li^{1

2}, Xinwei Hou^{1

2}, Fangfei Yang^{1

2}, Zhonghua Qin³

Affiliations

¹ Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, 300350, China.
² Tianjin Institute of Respiratory Diseases, Tianjin 300350, China.
³ Department of Laboratory, Haihe Hospital, Tianjin University, Tianjin, 300350, China.

Abstract

Aim: To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. Materials & methods: The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. Results: A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. Conclusion: COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset.

Keywords: COVID-19; IgG; IgM; SARS-CoV-2; antibody.