Recent Advances in Research on Polyphenols: Effects on Microbiota, Metabolism, and Health

Mol Nutr Food Res. 2022 Jan;66(1):e2100670. doi: 10.1002/mnfr.202100670. Epub 2021 Dec 2.


Polyphenols have attracted huge interest among researchers of various disciplines because of their numerous biological activities, such as antioxidative, antiinflammatory, antiapoptotic, cancer chemopreventive, anticarcinogenic, and antimicrobial properties, and their promising applications in many fields, mainly in the medical, cosmetics, dietary supplement and food industries. In this review, the latest scientific findings in the research on polyphenols interaction with the microbiome and mitochondria, their metabolism and health beneficial effects, their involvement in cognitive diseases and obesity development, as well as some innovations in their analysis, extraction methods, development of cosmetic formulations and functional food are summarized based on the papers presented at the 13th World Congress on Polyphenol Applications. Future implications of polyphenols in disease prevention and their strategic use as prophylactic measures are specifically addressed. Polyphenols may play a key role in our tomorrow´s food and nutrition to prevent many diseases.

Keywords: antioxidants; metabolites; microbiota; oxidative stress; polyphenols.

Publication types

  • Review

MeSH terms

  • Antioxidants / pharmacology
  • Functional Food
  • Gastrointestinal Microbiome*
  • Microbiota*
  • Polyphenols / metabolism
  • Polyphenols / pharmacology


  • Antioxidants
  • Polyphenols