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. 2023 May;25(5):497-502.
doi: 10.1080/10286020.2021.2004129. Epub 2021 Nov 21.

A new dimeric (-)-5-methylmellein from cultures of the basidiomycete Inonotus sinensis

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A new dimeric (-)-5-methylmellein from cultures of the basidiomycete Inonotus sinensis

Jian-Hai Ding et al. J Asian Nat Prod Res. 2023 May.

Abstract

(-)-5-Methylmellein (1) and its new dimer (2) were isolated from cultures of the basidiomycete Inonotus sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR. The structure of Compound 2 was determined by single-crystal X-ray crystallographic analysis. Compound 2 was tested for the cytotoxicities against five human cancer cell lines.

Keywords: (–)-5-methylmellein; (–)-5-methylmellein dimer; Inonotus sinensis; secondary metabolite.

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