Effect of acute and chronic ethanol administration in rats on PGE2 formation in microsomes from stomach and small intestine

Alcohol Alcohol Suppl. 1987:1:493-6.

Abstract

Prostaglandin E2 formation and content has been measured in the stomach and small intestine of rats after acute and chronic ethanol ingestion. Chronic ethanol administration for 6 and 12 weeks inhibits PGE2 synthesis and reduces PGE2 content (12 weeks) in all parts of the upper gastrointestinal tract, while after ethanol ingestion up to 1 week PGE2 synthesis is decreased only in the stomach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dinoprostone
  • Duodenum / drug effects
  • Ethanol / pharmacology*
  • Ileum / drug effects
  • Intestine, Small / drug effects*
  • Male
  • Microsomes / drug effects*
  • Microsomes / metabolism
  • Prostaglandins E / biosynthesis*
  • Rats
  • Rats, Inbred Strains
  • Stomach / drug effects*

Substances

  • Prostaglandins E
  • Ethanol
  • Dinoprostone